The molecular mechanisms operating in human organ transplant rejection are best inferred
from the mRNAs expressed in biopsies because the corresponding proteins often have low
expression and short half-lives, while small non-coding RNAs lack specificity. Associations
should be characterized in a population that rigorously identifies T cell-mediated (TCMR)
and antibody-mediated rejection (ABMR). This is best achieved in kidney transplant
biopsies, but the results are generalizable to heart, lung, or liver transplants. Associations …